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KMID : 0387420030140020095
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Korean Society of Oriental Neuropsychiatry
2003 Volume.14 No. 2 p.95 ~ p.105
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Comparative effects of Radix Polygalae and Rhizoma Acori Graminei on CT105-induced neuroblastoma cell lines
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Kim Hyung-Soo
Kim Sang-Tae
Kim Tae-Heon
Lyu Yeoung-Su
Kang Hyung-Won
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old age. In the future AD will be the largest problem in public health service. From old times, Much medicines have been used for treatment of dementia, but there is no medicine having obvious effect. AD is one of brain retrogression disease. So We studied on herbal medicine that have a relation of brain retrogression. From old times, In Oriental Medicine, Radix Polygalae and Rhizoma Acori Graminei have been used for disease in relation to brain retrogression. We studied of anti-Alzheimer effect on CT105-induced neuroblastoma cell lines by Radix Polygalae(RP) and Rhizoma Acori Graminei(RAG) water extract. As the result of this study, In RP and RAG group, the apoptosis in the nervous system is inhibited, the repair against the degeneration of Neuroblastoma cells by CT105 expression is induced. These results indicate that In RP and RAG, RAG possess the strongest in inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of Neuroblastoma cells by CT105 expression.
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KEYWORD
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Radix Polygalae, Rhizoma Acori Graminei, apoptosis, CT105(C-terminal 105)
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